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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEDD4L
All Species:
19.09
Human Site:
S377
Identified Species:
35
UniProt:
Q96PU5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96PU5
NP_001138436.1
975
111932
S377
G
G
E
E
P
T
P
S
V
A
Y
V
H
T
T
Chimpanzee
Pan troglodytes
XP_001140254
911
104904
I377
N
H
L
I
E
P
Q
I
R
R
P
R
S
L
S
Rhesus Macaque
Macaca mulatta
XP_001088661
1010
115306
S412
G
G
E
E
P
T
P
S
V
A
Y
V
H
T
T
Dog
Lupus familis
XP_533393
1027
117927
S429
G
G
E
E
P
T
P
S
V
A
Y
A
H
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFI0
1004
115400
S406
G
G
E
E
P
T
P
S
V
A
Y
V
H
T
T
Rat
Rattus norvegicus
Q62940
887
102376
V371
N
P
A
T
S
Q
P
V
T
S
S
N
H
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511197
1255
141275
H537
D
Q
P
D
A
A
C
H
L
Q
Q
Q
Q
E
S
Chicken
Gallus gallus
XP_424462
1045
119140
S447
G
G
E
E
P
T
P
S
V
A
Y
V
H
T
T
Frog
Xenopus laevis
Q2TAS2
751
86306
E255
H
T
P
P
D
L
P
E
G
Y
E
Q
R
T
T
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
F269
T
Q
Q
G
Q
V
Y
F
L
H
T
Q
T
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
T416
G
V
P
D
I
A
I
T
N
P
F
T
R
R
A
Honey Bee
Apis mellifera
XP_395191
782
90150
Q285
G
S
R
R
S
S
E
Q
I
E
S
P
K
P
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
N313
G
S
N
I
P
P
V
N
G
A
A
A
A
A
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.4
92.4
90.8
N.A.
94.3
48
N.A.
43.9
85.6
34.1
34.3
N.A.
47.2
49.4
N.A.
N.A.
Protein Similarity:
100
93.4
93.7
92.2
N.A.
95.6
60
N.A.
54
88.4
49
49.5
N.A.
61.8
61.1
N.A.
N.A.
P-Site Identity:
100
0
100
93.3
N.A.
100
13.3
N.A.
0
100
20
0
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
6.6
100
93.3
N.A.
100
33.3
N.A.
20
100
20
13.3
N.A.
26.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
16
0
0
0
47
8
16
8
8
8
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
16
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
39
39
8
0
8
8
0
8
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
8
% F
% Gly:
62
39
0
8
0
0
0
0
16
0
0
0
0
8
0
% G
% His:
8
8
0
0
0
0
0
8
0
8
0
0
47
0
0
% H
% Ile:
0
0
0
16
8
0
8
8
8
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
0
8
0
0
8
0
0
16
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
0
8
0
0
0
0
8
8
0
0
8
0
0
0
% N
% Pro:
0
8
24
8
47
16
54
0
0
8
8
8
0
8
0
% P
% Gln:
0
16
8
0
8
8
8
8
0
8
8
24
8
0
0
% Q
% Arg:
0
0
8
8
0
0
0
0
8
8
0
8
16
8
0
% R
% Ser:
0
16
0
0
16
8
0
39
0
8
16
0
8
8
24
% S
% Thr:
8
8
0
8
0
39
0
8
8
0
8
8
8
47
47
% T
% Val:
0
8
0
0
0
8
8
8
39
0
0
31
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
8
39
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _